Development of Stereotactic Mass Spectrometry for Brain Tumor Surgery
نویسندگان
چکیده
منابع مشابه
Development of stereotactic mass spectrometry for brain tumor surgery.
BACKGROUND Surgery remains the first and most important treatment modality for the majority of solid tumors. Across a range of brain tumor types and grades, postoperative residual tumor has a great impact on prognosis. The principal challenge and objective of neurosurgical intervention is therefore to maximize tumor resection while minimizing the potential for neurological deficit by preserving...
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For many intraoperative decisions surgeons depend on frozen section pathology, a technique developed over 150 y ago. Technical innovations that permit rapid molecular characterization of tissue samples at the time of surgery are needed. Here, using desorption electrospray ionization (DESI) MS, we rapidly detect the tumor metabolite 2-hydroxyglutarate (2-HG) from tissue sections of surgically re...
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ژورنال
عنوان ژورنال: Neurosurgery
سال: 2011
ISSN: 0148-396X,1524-4040
DOI: 10.1227/neu.0b013e3181ff9cbb